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Synthesis, antiretrovirus effects and phosphorylation kinetics of 3'-isocyano-3'-deoxythymidine and 3'-isocyano-2',3'-dideoxyuridine

โœ Scribed by Hiebl, Johann; Zbiral, Erich; Balzarini, Jan; De Clercq, Erik

Book ID
126041017
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
593 KB
Volume
33
Category
Article
ISSN
0022-2623

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An efficient total synthesis of 3โ€ฒ-azido
An efficient total synthesis of 3โ€ฒ-azido-3โ€ฒ-deoxythymidine (AZT) and 3โ€ฒ-azido-2โ€ฒ,3โ€ฒ-dideoxyuridine (AZDDU, CS-87) from D-mannitol
โœ Chung K Chu; J.Warren Beach; Giliyar V Ullas; Yoshiyuki Kosugi ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 231 KB

An efficient stereoselective total synthesis of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZDDU, CS-87) from readily available and inexpensive starting material, D-mannitol has been achieved. 3'-Azido-3'-deoxythymidine (AZT) has been found to be a potent antiviral agent ag