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Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2- a ]quinoxalines, Bispyrrolo[1,2- a ]quinoxalines, Bispyrido[3,2- e ]pyrrolo[1,2- a ]pyrazines, and Bispyrrolo[1,2- a ]thieno[3,2- e ]pyrazines

✍ Scribed by Guillon, Jean; Grellier, Philippe; Labaied, Mehdi; Sonnet, Pascal; Léger, Jean-Michel; Déprez-Poulain, Rébecca; Forfar-Bares, Isabelle; Dallemagne, Patrick; Lemaître, Nicolas; Péhourcq, Fabienne; Rochette, Jacques; Sergheraert, Christian; Jarry, Christian

Book ID
118128431
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
298 KB
Volume
47
Category
Article
ISSN
0022-2623

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## Abstract The synthesis of the title compounds was achieved using the key intermediate ethyl 4,6‐dimethyl‐3‐(pyrrol‐1‐yl)thieno[2,3‐__b__]pyridine‐2‐ carboxylate 2. This latter compound was obtained __via__ the interaction of the thienopyridine amino ester 1 with 2,5 dimethoxytetrahydrofuran in a