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Synthesis and13C NMR spectra of 5-alkyl-1,4-diaza- and 5-alkyl-1-aza-4-oxabicyclo [3.3.0]octan-8-ones

✍ Scribed by V. A. Sedavkina; I. V. Lizak; N. N. Sorokin


Book ID
112329781
Publisher
Springer US
Year
1987
Tongue
English
Weight
280 KB
Volume
23
Category
Article
ISSN
0009-3122

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Reactions of 4-Oxoalkanoic Acids, 4. Syn
✍ Wedler, Christine ;Schick, Hans ;Scharfenberg-Pfeiffer, Doris ;Reck, GΓΌnter πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 432 KB

## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Γ… in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (Β±)‐5‐alkyl‐4‐oxa‐1‐azab