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Synthesis and Transformation of Methyl 2-(6-Hydroxy-2-phenylpyrimidin-4-yl)acetate: Simple Preparation of Pyrimidines with Heterocyclic Substituents

✍ Scribed by David Bevk; Uroš Grošelj; Anton Meden; Jurij Svete; Branko Stanovnik

Book ID
102255826
Publisher
John Wiley and Sons
Year
2007
Tongue
German
Weight
108 KB
Volume
90
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

A simple and efficient synthesis of four new substituted pyrimidines, compounds 9a–d, from the title compound 3 is described. Conversion of 3 to methyl (E)‐3‐(dimethylamino)‐2‐(6‐methoxy‐2‐phenylpyrimidin‐4‐yl)prop‐2‐enoate (4), followed by condensation with various dinucleophiles according to the ‘enaminone methodology’, afforded the target compounds 9 in medium‐to‐good yields.

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