✦ LIBER ✦

Synthesis and reactions of 4-Hydroxy-2(1H)-pyridones with thienyl and pyridyl substituents in position 6 starting with azomethines and malonates

✍ Scribed by Barbara Schnell

Book ID: 102893933
Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 533 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360234

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✦ Synopsis

Abstract

The reaction of 4 with substituted diethyl malonates 5a, or “magic malonates” (bis‐2,4,6‐trichlorophenylmalonates 5b) leads to 4‐hydroxy‐2(1__H__)‐pyridones 6. The azomethines 4 are prepared via the Strecker compounds 3 starting with methyl ketones 1, anilines, and potassium cyanide. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 7 while nitration gives 9.

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