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Synthesis and Testing of Mechanism-Based Protein-Profiling Probes for Retaining Endo-glycosidases

✍ Scribed by Spencer J. Williams; Omid Hekmat; Stephen G. Withers


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
282 KB
Volume
7
Category
Article
ISSN
1439-4227

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Synthesis of symmetrical 4,4β€²- and 6,6β€²-
✍ Mehdi Abbadi; Geoffrey D. Holman; Christophe Morin; William D. Rees; Jing Yang πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 242 KB

Two glucose moieties have been linked from positions -4 or -6 and hydrophobic groups have been placed symmetrically between the hexose moities. To orossiink glucose and obtain 6,6'-probes, advantage has been taken of the unusual reactivity of D-glucurono-,t-lactone with amines. To obtain 4,4'linked