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Synthesis and study of a new adenine–acridine tandem, inhibitor of exonuclease III

✍ Scribed by Philippe Belmont; Martine Demeunynck; Jean-François Constant; Jean Lhomme

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
168 KB
Volume
10
Category
Article
ISSN
0960-894X

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✦ Synopsis

A new heterodimer adenine-chain-acridine containing a mixed amido-guanidinium linker chain was synthesized. To achieve the synthesis a new method of introduction of aminoalkyl chain at position 9 of adenine was designed. The heterodimer interacts specifically with the abasic sites in DNA and inhibits the major base excision repair enzyme in Escherichia coli, Exonuclease III.

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