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Synthesis and structure–activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists

✍ Scribed by Martin W Rowbottom; Fabio C Tucci; Yun-Fei Zhu; Zhiqiang Guo; Timothy D Gross; Greg J Reinhart; Qui Xie; R.Scott Struthers; John Saunders; Chen Chen


Book ID
108073254
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
281 KB
Volume
14
Category
Article
ISSN
0960-894X

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The synthesis and SAR studies of thieno [2,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists to treat reproductive diseases are discussed. It was found that the 2-(2-pyridyl)ethyl group on the 5-aminomethyl functionality of the core structure was a key feature for good receptor binding ac