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Synthesis and Structure−Activity Relationships of 6,7-Benzomorphan Derivatives as Antagonists of the NMDA Receptor−Channel Complex

✍ Scribed by Grauert, Matthias; Bechtel, Wolf Dietrich; Ensinger, Helmut A.; Merz, Herbert; Carter, Adrian J.


Book ID
120789395
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
354 KB
Volume
40
Category
Article
ISSN
0022-2623

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Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phos