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Synthesis and structure–activity relationship of new analogues of antistasin

✍ Scribed by Dr Dantcho L. Danalev; Lyubomir T. Vezenkov; Boryana Grigorova

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
129 KB
Volume
10
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

Intensive investigation connected with the development of new anticoagulant agents for the treatment of cardiovascular diseases was carried out. Direct and specific inhibition of thrombin and Factor Xa–like serine proteases in the coagulation cascade has been the focus of many efforts to design novel anticoagulants over the past decade. This work reports the synthesis and biological activity of new anticoagulant peptide analogues of natural isoforms 2 and 3 of antistasin. In addition they include different tripeptide sequences in their molecules, which are highly active inhibitors of different serine proteases such as plasmin, trypsin, thrombin and Factor Xa. Copyright © 2003 European Peptide Society and John Wiley & Sons, Ltd.

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