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Synthesis and structure–activity relationship of 2-thiopyrimidine-4-one analogs as antimicrobial and anticancer agents

✍ Scribed by Supaluk Prachayasittikul; Apilak Worachartcheewan; Chanin Nantasenamat; Maneekarn Chinworrungsee; Nirun Sornsongkhram; Somsak Ruchirawat; Virapong Prachayasittikul


Book ID
118435735
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
247 KB
Volume
46
Category
Article
ISSN
0223-5234

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N-Substituted-2-amino-4(3/-/)-7H-oxopyrrolo[2,3-d]pyrimidine-5-carboxamides and their ribofuranosyl and 2',3'-dideoxyribofuranosyl derivatives were ixcpared as membrane permeable ¢chiguanine analogs and tested for their ability to inhibit phosphatidylinositol (PI) 4-kinase. Compounds 5 and 6 were fo