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Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents

✍ Scribed by Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L. Morris-Natschke; Kenneth F. Bastow; Kuo-Hsiung Lee

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 210 KB
Volume: 21
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.10.074

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Antitumor agents 278. 4-Amino-2H-benzo[h

Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents

✍ Yizhou Dong; Kyoko Nakagawa-Goto; Chin-Yu Lai; Susan L. Morris-Natschke; Kenneth 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 252 KB

4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs were designed, synthesized, and evaluated for cytotoxic activity. Among all 4-substituted ABO analogs, cyclohexyl (12), N-methoxy-N-methylacetamide (14), and various aromatic derivatives (15-25 and 27) exhibited promising cell growth inhibitory activity