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Synthesis and structure–activity investigation of novel vasopressin hypotensive peptide agonists

✍ Scribed by Maurice Manning; Stoytcho Stoev; Ling Ling Cheng; Nga Ching Wo; W.Y. Chan


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
175 KB
Volume
5
Category
Article
ISSN
1075-2617

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✦ Synopsis


We report the solid phase synthesis and vasodepressor potencies of the novel hypotensive peptide [1(-i-mercapto-i,i-pentamethylene propionic acid)-2-O-ethyl-D-tyrosine, 3-arginine, 4-valine] arginine vasopressin, d(CH 2 ) 5 [D-Tyr(Et) 2 , Arg 3 , Val 4 ]AVP (A), its related Lys 3 (B), Tyr-NH 2 9 (C), [Lys 3 , Tyr-NH 2 9

] (D) analogs and in a preliminary structure -activity study of positions 2 -4 and 7 -9, 24 analogs (1 -24) of A -C.


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