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Synthesis and structure of novel 4-arylhexahydro-1H,3H-pyrido[1,2-c]pyrimidine derivatives

✍ Scribed by Franciszek Herold; Ewa Helbin; Marek Król; Irena Wolska; Jerzy Kleps

Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
514 KB
Volume
36
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of new 4‐aryl‐hexahydro‐1__H__,3__H__‐pyrido[1,2‐c]pyrirnidine‐1,3‐dione derivatives 4a‐k were prepared by catalytic hydrogenation of 4‐aryl‐1__H__,2__H__‐pyrido[1,2‐c]pyrirnidine‐1,3‐diones 3a‐k. The structures of compounds were determined by ^1^H and ^13^C nmr spectroscopy in solution. Steric hindrance caused twisting of the phenyl ring with respect to the pyridopyrimidine system, the effect was confirmed by X‐ray diffraction.

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