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Synthesis and molecular structure of novel 4-aryloctahydropyrido-[1,2-c]pyrimidine derivatives

✍ Scribed by Franciszek Herold; Jerzy Kleps; Beata Szczȩsna; Romana Anulewicz-Ostrowska

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
142 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of new 4‐aryloctahydropyrido[1,2‐c]pyrimidine‐1,3‐diones 6a,b,d‐h and j were synthesized by intramolecular cyclization of α‐aryl‐α‐(1‐ethoxycarbonyl‐2‐piperidyl)‐acetamide derivatives 5a,b,d‐h and j. The structures of compounds were determined by ^1^H and ^13^C nmr spectroscopy. Nmr and X‐ray diffraction data indicate that the configuration at the C4, C4a stereocenters constitute RR and SS pair.

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