The chemical synthesis of 3beta-bromobenzoyloxy-14alpha, 15alpha-epoxy-5alpha-cholest-7-ene is described. Single crystal structral analysis was employed to unambiguously determine the location and absolute configuration of the epoxide moiety in the 3beta-p-bromobenzoyloxy-14alpha, 15alpha-epoxy-5alp
Synthesis and structure determination of 3α-triphenylstannyl-cholest-5-ene
✍ Scribed by Heather J. Buchanan; Philip J. Cox; James L. Wardell
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 283 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1572-8854
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📜 SIMILAR VOLUMES
Although most cholestenes of the 56 series have been throughly investigatea' only few informations can be found in the literature about the analogous 5P-derivatives. It has been reported, for instance, that 5)3-cholestan-3/j-01 tosylate is transformed by alumina into 5P-cholest-2-ene,' and that the
Treatment of 3~-benzoyloxy-14c¢,l 5~-epoxy-5a-cholest-7-ene (I) with gaseous HCI in chloroform at 40°C gave, in 87% yield, 3#-benzoyloxy-7a,1513-dichloro-5a-cholest-8(14)-ene (111). Reduction of the latter compound with lithium aluminum hydride in ether at room temperature for 20 min gave, in 86% yi