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Synthesis and structure-activity relationships in a novel series of topically active corticosteroids

โœ Scribed by Michael J. Green; Joseph Berkenkopf; Xiomara Fernandez; Margaret Monahan; Ho-Jane Shue; Robert L. Tiberi; Barry N. Lutsky

Book ID
116001676
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
546 KB
Volume
11
Category
Article
ISSN
0022-4731

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Synthesis and structureโ€“analgesic activi
Synthesis and structureโ€“analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ)
โœ Song-Wen Lin; Qi Sun; Ze-Mei Ge; Xin Wang; Jia Ye; Run-Tao Li ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 293 KB

A series of monospirocyclopiperazinium salts were designed and synthesized to search for a peripherally-acting analgesic drug with low side effects. Extensive SAR studies revealed that a suitable NR(2)R(3) was critical for the analgesic activity, which might be beneficial to expose the cationic nitr