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Structure-activity relationship of novel tallimustine derivatives: synthesis and antitumor activity

โœ Scribed by Pier Giovanni Baraldi; Italo Beria; Barbara Cacciari; Laura Capolongo; Paolo Cozzi; Nicola Mongelli; Romeo Romagnoli; Giampiero Spalluto


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
206 KB
Volume
6
Category
Article
ISSN
0960-894X

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## Abstract Betaโ€carboline alkaloids such as harmine are present in medicinal plants such as __Peganum harmala__ that have been used as folk medicine in anticancer therapy. In our study, 9 harmine derivatives (including harmine) were investigated for their antitumor effects and acute toxicities in