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Synthesis and steric structure of cis- and trans-alicycle-fused dihydrothiazepines

✍ Scribed by P. Sohár; K. Újszászy; J. Szabó; L. Simon; G. S. Talpas; L. Fodor; G. Bernáth

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
459 KB
Volume
29
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

β‐Lactam‐condensed saturated thiaazabicycles underwent ring transformation to give a new type of alicycle‐fused 3‐phenyl‐2‐methoxycarbonyl‐4,5‐dihydro‐1,4‐thiazepine. Oxidation of the cis and trans cyclohexane derivatives with perbenzoic acid furnished sulphones. The configurations and conformations of the new compounds were confirmed by ^1^H and ^13^C NMR spectroscopy, making use of DR, DNOE, DEPT and 2D HSC measurements.

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