Synthesis and stereochemistry of sarcophytol B: An anticancer cembranoid

✍ Scribed by John E. McMurry; Joseph G. Rico; You-nan Shih

• Book ID: 104214035
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 218 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)72708-0

✦ Synopsis

A short (5 step), efficient synthesis of sarcophytol B (1) from farnesal is reported using a low-temperature, titanium-induced pinacol coupling reaction of 1 ,lCdialdehyde 5 as the key step. An X-ray structure determination showed that sarcophytol B has trans diol stereochemistry.