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Synthesis and stereochemical study of cis- and trans-1-(3′-substituted-propyl)benzo[a]quinolizidine

✍ Scribed by Jenõ Kóbor; Pál Sohár; Ferenc Fülöp

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 902 KB
Volume: 50
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)85022-5

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✦ Synopsis

AbstracL -From I-methyl-6,7-dimetlzq-3,4_dihydroisoquinoline widt methyl or efhyl aqiate or with acrylonitile, via Michael addition products, cis-and trans-l-(3'-substi~ted-propyl)benw[a]~it~oIi~idinotaes and quinokidines were prepared. 77le relative configurations and the predominant conformations were determined by means of 1H and 13C NMR spectroscopy, with the application of DR, DNOE and 20 HSC measurements.

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