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Synthesis and spectroscopic properties of novel polyfunctionally substituted 2,6- and 2,7-naphthyridines

✍ Scribed by Isabel Amalia Perillo; Lautaro Diego Kremenchuzky; María Mercedes Blanco

Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
361 KB
Volume
921
Category
Article
ISSN
0022-2860

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✦ Synopsis

Series of 5,6-dihydro-8-hydroxy-5-oxo-2,6-naphthyridine-7-carboxylic acid derivatives (2,4) and the isomeric 7,8-dihydro-5-hydroxy-8-oxo-2,7-naphthyridine-6-carboxylic acid derivatives (3,5) having potential pharmacological activity were synthesized from 3,4-pyridinedicarboxylic acid derivatives. Spectroscopic data (IR, 1 H-and 13 C-NMR, MS) are analyzed and support the enol-lactam structure of compounds 2-5 in solution, solid state and gas phase. Results in the different series (2,6-vs 2,7-naphthyridines and N-unsubstituted lactam vs N-methyl derivatives) are compared, and common and differential features amongst them are indicated.

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