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One-pot synthesis of polyfunctionally substituted 2,3-dihydrothiazoles and thiazolidinones

✍ Scribed by Mohareb, Rafat M. ;Sherif, Sherif M. ;Abdel-Aal, Fatma A. M. ;Sayed, Nadia I. A.

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
346 KB
Volume
1990
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The reaction of phenyl isothiocyanate with the active methylene reagents 1a–e gives the nonisolable 1:1 adducts 2a–e. The latter react with α‐halogenated compounds, e.g. phenacyl bromide, bromoacetyl bromide, chloroacetone, chloroacetonitrile and some hydrazonoyl halides to give the corresponding polyfunctionally substituted 2,3‐dihydrothiazoles or thiazolidinone ring systems.

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3,4a]benzimidazoles 2-Mercaptoacetic acid and aromatic aldehyde a b s t r a c t An expeditious one-pot synthesis of 2,3-diaryl/2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones and 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles have been accomplished by condensing hetero/aromatic amine, 2-mercaptoacetic acid,