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Synthesis and SAR of 4-Aryl-2-hydroxy-4-oxobut-2-enoic Acids and Esters and 2-Amino-4-aryl-4-oxobut-2-enoic Acids and Esters: Potent Inhibitors of Kynurenine-3-hydroxylase as Potential Neuroprotective Agents

✍ Scribed by Drysdale, Martin J.; Hind, S. Lucy; Jansen, Marilyn; Reinhard, John F.

No coin nor oath required. For personal study only.

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## Abstract All compounds are purified by recrystallization from an aprotic, non‐polar solvent like toluene and hexane.