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ChemInform Abstract: Synthesis and SAR of 4-Aryl-2-hydroxy-4-oxobut-2-enoic Acids and Esters and 2-Amino-4-aryl-4-oxobut-2-enoic Acids and Esters: Potent Inhibitors of Kynurenine-3-hydroxylase as Potential Neuroprotective Agents.

โœ Scribed by Martin J. Drysdale; S. Lucy Hind; Marilyn Jansen; John F. Reinhard Jr.


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis, Properti
โœ A. V. MILYUTIN; L. R. AMIROVA; I. V. KRYLOVA; F. YA. NAZMETDINOV; G. N. NOVOSELO ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB

Synthesis, Properties and Biological Activity of 3-Pyridylamides of 4-Aryl-2-hydroxy-4-oxo-2-butenoic (Aroylpyruvic) Acids. -A number of title pyridylamides (III) (11 examples) is synthesized and transformed into carbamoyl-substituted N-heterocyles (cf. (IV), (V), ( VIII)) and quinoxalones (VII). A