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ChemInform Abstract: Synthesis, Properties and Biological Activity of 3-Pyridylamides of 4- Aryl-2-hydroxy-4-oxo-2-butenoic (Aroylpyruvic) Acids.

✍ Scribed by A. V. MILYUTIN; L. R. AMIROVA; I. V. KRYLOVA; F. YA. NAZMETDINOV; G. N. NOVOSELOVA; YU. S. ANDREICHIKOV; V. E. KOLLA

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199730135

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✦ Synopsis

Synthesis, Properties and Biological Activity of 3-Pyridylamides of 4-Aryl-2-hydroxy-4-oxo-2-butenoic (Aroylpyruvic) Acids.

-A number of title pyridylamides (III) (11 examples) is synthesized and transformed into carbamoyl-substituted N-heterocyles (cf. (IV), (V), ( VIII)) and quinoxalones (VII). All the compounds synthesized show activity against S. aureus and E. coli as well as analgesic activity. They also possess antiinflammatory properties. Structure-activity relationships are discussed.

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