Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents

✍ Scribed by Xenia Beebe; Angela M. Nilius; Philip J. Merta; Niru B. Soni; Mai H. Bui; Rolf Wagner; Bruce A. Beutel

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 157 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00727-3

✦ Synopsis

The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4-b]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with alpha-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest Haemophilus influenzae antibacterial activity.