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Synthesis and SAR Evaluation of Oxadiazolopyrazines as Selective Haemophilus influenzae Antibacterial Agents.

โœ Scribed by Xenia Beebe; Angela M. Nilius; Philip J. Merta; Niru B. Soni; Mai H. Bui; Rolf Wagner; Bruce A. Beutel


Publisher
John Wiley and Sons
Year
2003
Weight
93 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis and SAR evaluation of oxadiazo
โœ Xenia Beebe; Angela M. Nilius; Philip J. Merta; Niru B. Soni; Mai H. Bui; Rolf W ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 157 KB

The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4-b]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with alpha-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest