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Synthesis and Ring Opening of Methyl 2-Alkyl-3-(alkyl/aryl)-1-benzoylaziridine-2-carboxylates: Synthesis of Polysubstituted Amino Acids

✍ Scribed by Carmela Papa; Claudia Tomasini


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
284 KB
Volume
2000
Category
Article
ISSN
1434-193X

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✦ Synopsis


Aziridines / Oxazolines / Ring expansion reactions / Ξ±-Hydroxy Ξ²-amino acids / Ξ²-Hydroxy Ξ±-amino acids A new method for the preparation of 2,2,3-trisubstituted methyl 1-benzoylaziridine-2-carboxylates is reported. These compounds have been obtained starting from Ξ±-alkyl Ξ²amino acids by formation of the lithium dianion and reaction with iodine. The aziridines undergo ring expansion or ring


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