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Synthesis and reactivity of high-molecular-mass phosphorylated poly(ethylene glycol)

✍ Scribed by Giacomo Pace; Francesco Maria Veronese; Gian Maria Bonora

Book ID
104425753
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
150 KB
Volume
41
Category
Article
ISSN
1381-5148

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## Abstract Reductively degradable multiblock polymers for gene and drug delivery were synthesised by oxidative polycondensation of poly(ethylene glycol)‐cysteine derivatives containing ester or urethane bonds. Hydrolysis of the polymers at pH = 5.5, 7.4 and 8.0 and reductive degradation with gluta