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Hydrolytically and Reductively Degradable High-Molecular-Weight Poly(ethylene glycol)s

✍ Scribed by Alena Braunová; Michal Pechar; Richard Laga; Karel Ulbrich

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
278 KB
Volume
208
Category
Article
ISSN
1022-1352

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✦ Synopsis

Abstract

Reductively degradable multiblock polymers for gene and drug delivery were synthesised by oxidative polycondensation of poly(ethylene glycol)‐cysteine derivatives containing ester or urethane bonds. Hydrolysis of the polymers at pH = 5.5, 7.4 and 8.0 and reductive degradation with glutathione and dithiothreitol were studied. The hydrolysis rate of polymer esters increased with increase in pH; the hydrolysis of polymer urethanes was negligible. Chemical substitution of the pendant COOH or NH~2~ groups significantly affected the rate of the polymer degradation. Surface modification of poly(L‐lysine)‐DNA complexes with PEG‐cystine multiblocks led to the formation of reductively degradable nanoparticles.

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