MultiPEGs: High Molecular Weight Multifunctional Poly(ethylene glycol)s Assembled by a Dendrimer-Like Approach
✍ Scribed by Maurizio Ballico; Sara Drioli; Gian M. Bonora
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 202 KB
- Volume
- 2005
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Abstract
New multifunctional, soluble and biocompatible polymeric systems exhibiting good physicochemical properties and good binding capacity have been obtained by assembly of smaller PEG components, selectively protected, purified and activated, by use of appropriate polyfunctional linkers. A general process for the synthesis of those derivatives was characterized by: a) selective derivatization of a PEG unit with a defined MW with an appropriate protecting group and activation of residual functional groups, and b) multiple condensation reactions of PEG units and linkers to provide multifunctional polyethylene glycol derivatives (MultiPEGs) of the desired size and complex structure. These complex‐structured MultiPEGs have larger numbers of functional groups, and probably better biodegradability, than commercial PEGs of comparable molecular weight. They can be advantageously used as carriers or stabilizers of pharmacologically or biologically active substances, and also as soluble supports for reagents and catalysts in liquid‐phase synthesis reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)