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Synthesis and Radiolabelling of Ipratropium and Tiotropium for Use as PET Ligands in the Study of Inhaled Drug Deposition

✍ Scribed by Issa, Fatiah; Kassiou, Michael; Chan, Hak-Kim; McLeod, Malcolm D.

Book ID: 115542291
Publisher: Commonwealth Scientific and Industrial Research Organisation Publishing
Year: 2006
Tongue: English
Weight: 201 KB
Volume: 59
Category: Article
ISSN: 0004-9425
DOI: 10.1071/ch05303

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## Abstract Synthetic routes to __pseudo‐geminal__, __pseudo‐ortho__ and __ortho__ hydroxy‐oxazolinyl[2.2]paracyclophanes (and the diastereoisomers of each) for use as N,O ligands in asymmetric catalysis have been devised. The substitution pattern was found to have a strong effect on the rate and e