Synthesis and radioiodination of N-Boc-p-(tri-n-butylstannyl)-L-phenylalanine tetrafluorophenyl ester: Preparation of a radiolabeled phenylalanine derivative for peptide synthesis
β Scribed by Wilbur, D. Scott; Hamlin, Donald K.; Srivastava, Rajiv R.; Burns, H. Donald
- Book ID
- 126934741
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 875 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1043-1802
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An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogr
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