𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and purification of 2-bromo-α-ergocryptine-82Br

✍ Scribed by S. P. Markey; R. W. Colburn; I. J. Kopin

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
164 KB
Volume
12
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Bromocryptine (2-brom-a-ergocryptine, I) has been found t o be a dopamine agonist used f o r treatment of endocrine disorders and more recently f o r the treatment of Parkinsonism (12'). metabolism and pharmacokinetic studies, a radiolabelled drug was desired.

Recent studies have demonstrated the u t i l i t y of 82Br labelled drugs prepared by synthesis (3) o r d i r e c t neutron irradiation (4). W e have In order t o perform chosen synthesis t o avoid decomposition anticipated from recoil labelling.

A d i l u t e solution of a-ergocryptine (11) was found to react specifically

📜 SIMILAR VOLUMES

Inhibition of mammary tumorigenesis in G
Inhibition of mammary tumorigenesis in GR mice with 2-bromo-α-ergocryptine
✍ Clifford W. Welsch; Margaret Goodrich-Smith; Carolyn K. Brown; Mark Wilson 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 486 KB

## Abstract A high incidence of mammary tumors is found in multiparous GR mice during the 2nd and 3rd pregnancies and in nulliparous GR mice treated with estrone/progesterone. The purpose of this study was to determine if prolactin is a contributing hormone in the genesis of these neoplasms. In one

Synthesis of 2-deoxy-2[82Br]bromo-d-mann
Synthesis of 2-deoxy-2[82Br]bromo-d-mannose and related compounds and their biodistributions in mice
✍ Yi-Guo Zhou; Chyng-Yann Shiue; Alfred P. Wolf; Carroll D. Arnett 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 563 KB

The synthesis of 2-deoxy-2-[82Br]bromo-3,4,6-tri-O-acetyl-alpha-D-mannopyranosyl chloride (compound 3b) and 2-deoxy-2-[82Br]bromo-D-mannose (compound 4b), and their biodistributions in mice are described. The reaction of 3,4,6-tri-O-acetyl-D-glucal (compound 2) with unlabeled and labeled bromine chl