Synthesis and properties of tachyplesin I, a lipopolysaccharide-binding peptide, from Tachypleus tridentatus
โ Scribed by Tiee-Cherng Shieh; Takuji Kohzuma; Nam Gyu Park; Motonori Ohno; Takanori Nakamura; Sadaaki Iwanaga; Tatsuto Yamamoto
- Book ID
- 115922056
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 302 KB
- Volume
- 252
- Category
- Article
- ISSN
- 0014-5793
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Macrocyclic receptor 9, has been prepared in homochiral form. The receptor shows selectivity for cextain dipeptides, and most notably a strong prefea, ence for N-Clyz-l~-alanyl amino acids ovetN-Cbz-~alanyl lactic acids.
Macrocyclic receptor 1 has been synthesised, as a racemate and as a single enantiomer, utilising a Stille coupling for the formation of the biphenyl portion and a macrolactamisation as the final step. The binding properties for the racemic and the homochiral macrocycle with amino acid and dipeptide