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Synthesis and properties of oligodeoxyribonucleotides containing 4-N-acetylcytosine bases

✍ Scribed by Takeshi Wada; Akio Kobori; Shun-ichi Kawahara; Mitsuo Sekine

Book ID
104259811
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
265 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Oligodeoxyribonucleotides containing 4-N-acetyl-2'-deoxycytidines (ac4dC) were synthesized by the H-phosphonate method. Thymidine 3'-O-(3,4-dichloro)phthalate bound to a solid support was employed as the starting material for the solid-phase synthesis. The (3,4-dichloro)phthaloyl (DCP) linker was found to be cleaved by treatment with 10% DBU in CH3CN for 5 min without loss of the 4-N-acetyl group of 2'-deoxycytidine. The thermal stability of the duplexes containing ac4dC was investigated.

πŸ“œ SIMILAR VOLUMES

Conformational Studies of 4-N-Carbamoyld
Conformational Studies of 4-N-Carbamoyldeoxycytidine Derivatives and Synthesis and Hybridization Properties of Oligodeoxyribonucleotides Incorporating these Modified Bases
✍ Kenichi Miyata; Akio Kobori; Ryuji Tamamushi; Akihiro Ohkubo; Haruhiko Taguchi; πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 370 KB

## Abstract Deoxycytidine derivatives modified with various __N__‐substituted carbamoyl groups at the 4‐amino group were synthesized. The detailed ^1^H NMR studies suggest that the 3β€²,5′‐__O__‐disilylated __N__‐carbamoyldeoxycytidine derivative **11** exists as a species having an intramolecular hy