Synthesis and properties of n-trimethylgermylmethyl-n-nitrosourea, a germanium analogue of n-neopentyl-n-nitrosourea
โ Scribed by Yoshiro Sato; Shin-ichi Ninomiya; Feng-Zhi Liu; Naohiro Shirai; Yutaka Kawazoe
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 272 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
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14C N-2-hydroxyethyl-N-nitrosourea was prepared at a specific activity of 30 mCi/mmol and 1 . 2 9 mCi/mmol by a two-step synthetic sequence using 14C ethanolamine as the labelled precursor. Its puri-fication was performed by IiPLC using a Lichrosorb-DIOL column eluted by ethyl ether.The overall radi
## Abstract N[^14^C]โmethylurea and sodium nitrite were administered simultaneously to rats by stomach tube in order to demonstrate methylation of the nucleic acids due to the formation in the stomach of the corresponding nitrosamide, N[^14^C]โmethylโNโnitrosourea. The ionโexchange chromatograms of