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Synthesis and Properties of Ester-Linked Peptide Nucleic Acid Prodrug Conjugates

✍ Scribed by Bendifallah, Nadia; Kristensen, Edward; Dahl, Otto; Koppelhus, Uffe; Nielsen, Peter E.

Book ID
127245172
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
10 KB
Volume
14
Category
Article
ISSN
1043-1802

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## Abstract Peptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or D