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Synthesis and properties of cyclic gomesin and analogues

✍ Scribed by Alessandra Machado; Marcos A. Fázio; Antonio Miranda; Sirlei Daffre; M. Teresa Machini


Book ID
118285936
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
378 KB
Volume
18
Category
Article
ISSN
1075-2617

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## Abstract Gomesin (__Gm__) is a potent antimicrobial peptide isolated from the spider Acanthoscurria gomesiana. The two disulfide bridges Cys^2,15^ and Cys^6,11^ facilitate the folding of the molecule in a β‐hairpin structure, conferring on the peptide a high stability in human plasma. We report