Synthesis and Properties of Cholesteryl-Modified Triple-Helix Forming Oligonucleotides Containing a Triglycyl Linker
β Scribed by Vu, Huynh; Hill, Theresa Schmaltz; Jayaraman, Krishna
- Book ID
- 120177387
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 366 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1043-1802
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An improved protocol for the synthesis of oligonucleotides synthesized and the corresponding triplexes have been analyzed by thermal denaturation experiments and CD containing a 3ΠΟͺ3Π phosphodiester linkage, for use in an alternate strand triple-helix formation approach, is reported. spectroscopy. T
The synthesis of a new ribonucleoside analogue, which combines two modifications, namely a 2%-aminoethoxy side-chain on the ribose and a 5-methyl-1H-pyrimidin-2-one ( 4H T) unit as a base replacement, is presented. This building block was incorporated into triplex forming oligonucleotides and the bi