Synthesis and properties of 2-substituted estra-4, 9-dien-17β-ol-3-one derivatives
✍ Scribed by A. A. Shishkina; T. I. Ivanenko; K. K. Pivnitskii
- Book ID
- 112397296
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 503 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0091-150X
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The synthesis of a new progestomimetic steroid, analogous to the cetaloxopromegestone precursor of Trimegestone has been carried out in eight steps from 9α-hydroxyandrost-4-
## Abstract Starting with catalytic tritiation of 3‐methoxy‐estra‐1,3,5(10),8,14‐pentaen‐17B‐01 (1) the preparation of 17B‐hydroxy‐[14α,15α ‐^3^H] estra‐4,9‐dien‐3‐one (5) is described. The dienone (5) was obtained with a specific activity of 400 GBq/mmol and a radiochemical purity better than 96%.
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