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Synthesis and preliminary evaluation of 68Ga labelled bis-DOTA-benzylidene-bis-(indolecarboxylic acid hydrazide) for in vivo visualization of necrosis using PET

โœ Scribed by Kristof Prinsen; Marlein Miranda Cona; Junjie Li; Yicheng Ni; Alfons Verbruggen


Book ID
116799578
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
178 KB
Volume
37
Category
Article
ISSN
0969-8051

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N,N'-bis(diethylenetriamine pentaacetic acid)-3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) (bis-DTPA-BI) was radiolabeled with (99m)Tc(CO)(3). The resulting (99m)Tc(CO)(3)-bis-DTPA-BI was characterized (LC-MS) and evaluated as a potential SPECT tracer for imaging of necrosis in Wistar rats wi