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Synthesis and biological evaluation of 68Ga labeled bis-DOTA-3,3′-(benzylidene)-bis-(1H-indole-2-carbohydrazide) as a PET tracer for in vivo visualization of necrosis

✍ Scribed by Prinsen, Kristof; Cona, Marlein Miranda; Cleynhens, Jan; Vanbilloen, Hubert; Li, Junjie; Dyubankova, Natalia; Lescrinier, Eveline; Bormans, Guy; Ni, Yicheng; Verbruggen, Alfons


Book ID
121788529
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
672 KB
Volume
23
Category
Article
ISSN
0960-894X

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N,N'-bis(diethylenetriamine pentaacetic acid)-3,3'-(benzylidene)-bis-(1H-indole-2-carbohydrazide) (bis-DTPA-BI) was radiolabeled with (99m)Tc(CO)(3). The resulting (99m)Tc(CO)(3)-bis-DTPA-BI was characterized (LC-MS) and evaluated as a potential SPECT tracer for imaging of necrosis in Wistar rats wi