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Synthesis and Photophysical Characterization of a New, Highly Hydrophilic Caging Group

✍ Scribed by Klaus Schaper; S. Abdollah Madani Mobarekeh; Christof Grewer

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
420 KB
Volume
2002
Category
Article
ISSN
1434-193X

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✦ Synopsis

o-Nitrobenzyl-protected bioactive compounds are useful tools in biophysics, allowing controlled photorelease of biologically active compounds with high temporal and spatial precision. Thus, it is possible to study biological processes, such as neurotransmitter-receptor interaction, and many other processes, in much more detail than before. In this respect, these caged compounds have become established as extremely useful tools. In some cases, however, their biological properties (the caged compound should not interact with the biological system), their photochemical properties (quantum yield and kinetics of the photorelease), and their physical properties (high hydrophilicity) are not satisfactory. In order

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