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Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5′-sulfonamide moiety of phenyl ring

✍ Scribed by Dae-Kee Kim; Ju Young Lee; Hyun-Ju Park; Khac Minh Thai


Book ID
108073265
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
388 KB
Volume
14
Category
Article
ISSN
0960-894X

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✍ Huan-Ming Chen; Ramachandra S. Hosmane; Donna M. Baldisseri 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 217 KB

## Abstract The synthesis of a novel ring‐expanded nucleoside analogue, (Z)‐1‐((2‐Guanidinocarbamoyl‐cyclopropylidene)methyl)‐4,5,7,8‐tetrahydro‐6__H__‐6‐iminoimidazo[4,5‐__e__][1,3]diazepine‐4,8‐dione (**1**) has been reported. It was prepared starting from methyl imidazole‐4,5‐dicarboxylate by se