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Synthesis and Pharmacology of Seleninic Acid Analogues of the Inhibitory Neurotransmitter γ-Aminobutyric Acid

✍ Scribed by Stuhr-Hansen, Nicolai; Ebert, Bjarke; Krogsgaard-Larsen, Povl; Kehler, Jan


Book ID
127043941
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
46 KB
Volume
2
Category
Article
ISSN
1523-7060

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## Abstract The synthesis of a new radioligand, which binds with high selectivity and affinity (K~D~ = 7.4 nM) to the GABA‐B receptor, is described. A Wittig‐Horner approach was employed to prepare an unsaturated protected intermediate (6), suitable for tritiation and deprotection.