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Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

✍ Scribed by J?rgensen, Charlotte G.; Clausen, Rasmus P.; Hansen, Kasper B.; Br?uner-Osborne, Hans; Nielsen, Birgitte; Bj?rn Metzler, ; Kehler, Jan; Krogsgaard-Larsen, Povl; Madsen, Ulf


Book ID
111689666
Publisher
Royal Society of Chemistry
Year
2007
Tongue
English
Weight
303 KB
Volume
5
Category
Article
ISSN
1477-0520

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Regioisomeric 3-hydroxyisoxazolinyl prolines [HIP-A (+)-6 and HIP-B (+)-7], which represent a restricted conformation of NMDA, AMPA, and kainic acid, potent and selective agonists at ionotropic glutamate receptors, have been prepared through two different strategies. In the first approach bromonitri