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Ibotenic Acid Analogues. Synthesis, Molecular Flexibility, and in Vitro Activity of Agonists and Antagonists at Central Glutamic Acid Receptors

✍ Scribed by Lauridsen, Jørn; Honoré, Tage; Krogsgaard-Larsen, Povl


Book ID
121432401
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
700 KB
Volume
28
Category
Article
ISSN
0022-2623

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✍ Konstantinos Papadopoulos; Douglas W Young 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 131 KB

The activated b-lactam aldehydes 31 and 55 were synthesised and found to be excellent substrates for our 'ring switching' strategy for preparation of libraries of homochiral compounds with potential for activity at specific glutamate receptor sub-types. The product heteroaromatic glycine derivatives