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Synthesis and pharmacology of a pargyline analog, N-3-(1 -butynyl)-benzylamine

✍ Scribed by Jerome F. Siuda; Carole Cihonski; R. Duane Sofia; Joseph P. Buckley

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
244 KB
Volume
62
Category
Article
ISSN
0022-3549

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✦ Synopsis

The synthesis of a structural isomer of pargyline was undertaken to test certain structure-activity relationships. I n uioo, the new compound, N-34 1-butyny1)-benzylamine. exhibited slight central stimulant effects but showed no MA0 inhibitory activity in uitro.

Keyphrases 0 N-3-(l-Butynyl)-benzylamine (pargyline analog)-synthesis and pharmacology, structure-activity relationships 0 Pargyline analog-synthesis and pharmacology of N-3-(l-butynyl)benzylamine, structureactivity relationships 0 M A 0 inhibitorssynthesis and pharmacology of pargyline analog, N-34 1-butyny1)benzylamine, structureactivity relationships 3M2 ( 1950).

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Synthesis of [14C]-pargyline {N-methyl-N
Synthesis of [14C]-pargyline {N-methyl-N-([1-14C]-propargyl)benzylamine} with the radioactive label on the propargyl group
✍ David J. W. Goon; James A. Elberling; E. G. Demaster; Herbert T. Nagasawa πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 French βš– 245 KB

## Abstract A one‐pot reaction scheme leading to ^14^C‐labeled pargyline (N‐methyl‐N‐ propargylbenzylamine) where in the radioactive label from [^14^C]‐formaldehyde is synthetically incorporated into the methylene group of the propargyl side chain is described. Thus, [^14^C]‐formaldehyde (aqueous s